does l carnitine cause insomnia

Brevetti, G., di Lisa, F., Perna, S., Menabo, R., Barbato, R., Martone, V. D., and Siliprandi, N. Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy. Sci Rep. 2016;6:19188. J NeuroAIDS. de Lira-Garcia, C., Souto-Gallardo, M., Bacardi-Gascon, M., and Jimenez-Cruz, A. To determine the dose and tolerability we conducted a phase II study with increasing doses of L-carnitine supplementation. View abstract. There are few negative side effects from this supplement at reasonable doses. Carnitine is also synthesized endogenously in the liver . Lee BJ, Lin JS, Lin YC, Lin PT. View abstract. Am J Clin Nutr 1980;33(7):1489-1492. Cuturic, M., Abramson, R. K., Moran, R. R., and Hardin, J. W. Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. Eur J Heart Fail. View abstract. Huang, Y., Huang, L. C., and Zhan, F. Clinical analysis of therapeutic effect of levocarnitine on dialysis patients. It can also cause a "fishy" odor of the urine, breath, and sweat. Pande, S., Brion, L. P., Campbell, D. E., Gayle, Y., and Esteban-Cruciani, N. V. Lack of effect of L-carnitine supplementation on weight gain in very preterm infants. 2009;9:53. Sun, Z. J., Yang, C. B., Wang, H., and Li, Y. Campos Y, Arenas J. A., and Greenhaff, P. L. Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans. Additional anti-ischemic effects of long-term L-propionylcarnitine in anginal patients treated with conventional antianginal therapy. Pediatr.Neurol. Intensive Care Med. Eur Heart J 1984;5(Abstr Suppl 1):138. Pastoris, O., Dossena, M., Foppa, P., Catapano, M., Arbustini, E., Bellini, O., Dal Bello, B., Minzioni, G., Ceriana, P., and Barzaghi, N. Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. View abstract. Lancet 12-13-1980;2(8207):1309-1310. Ann Neurol 1994;35:482-7. Neurobiol Aging 1995;16:1-4. 2009;79(3):131-141. View abstract. Santo, S. S., Sergio, N., Luigi, D. P., Giuseppe, M., Margherita, F., Gea, O. C., Roberto, F., Gabriella, C., Giuseppe, P., and Massimiliano, A. View abstract. Martinotti, G., Andreoli, S., Reina, D., Di, Nicola M., Ortolani, I., Tedeschi, D., Fanella, F., Pozzi, G., Iannoni, E., D'Iddio, S., and Prof, L. J. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. 2006;142(4):458-460. View abstract. Li, B., Lloyd, M. L., Gudjonsson, H., Shug, A. L., and Olsen, W. A. Shakeri, A., Tabibi, H., and Hedayati, M. Effects of L-carnitine supplement on serum inflammatory cytokines, C-reactive protein, lipoprotein (a), and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia. Hiatt WR, Regensteiner JG, Creager MA, et al. Shahidi M, Hashemi SR, Fattahi N, et al. View abstract. Rueda, J. R., Ballesteros, J., and Tejada, M. I. View abstract. Costa, M., Canale, D., Filicori, M., D'lddio, S., and Lenzi, A. L-carnitine in idiopathic asthenozoospermia: a multicenter study. For these reasons, L-carnitine supplements are only necessary in special cases, such as disease treatment. To make sure L-Carnitine is safe for you, tell your doctor if you have: kidney disease (or if you are on dialysis); if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests. (56-58) L-carnitine levels may be decreased in hypothyroidism, potentially due to reduced synthesis of L-carnitine while we are in a . In children, L-carnitine has most often been used in doses of 50-100 mg/kg by mouth daily, for up to one year. J Cardiopulm.Rehabil.Prev. View abstract. Int.J Cardiol. Eur.J Gastroenterol.Hepatol. Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients. "Product Information. Of the different forms, acetyl-L-carnitine and L-carnitine are the most popular and seem to be most effective. Tarighat, Esfanjani A., Mahdavi, R., Ebrahimi, Mameghani M., Talebi, M., Nikniaz, Z., and Safaiyan, A. Drugs Exp Clin Res 1990;16:101-6. Remington, R., Chan, A., Paskavitz, J., and Shea, T. B. Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer's disease: a placebo-controlled pilot study. View abstract. Zanardi, R. and Smeraldi, E. A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia. View abstract. Malaguarnera, M., Pistone, G., Astuto, M., Vecchio, I., Raffaele, R., Lo, Giudice E., and Rampello, L. Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. Control of valproate-induced hepatotoxicity with carnitine. 2001;37(5):1018-1028. Preliminary report. Beneficial effects of L-carnitine in post dialysis syndrome. View abstract. L-acetylcarnitine as a new therapeutic approach for peripheral neuropathies with pain. Nutr.Res. Miguel-Carrasco, J. L., Mate, A., Monserrat, M. T., Arias, J. L., Aramburu, O., and Vazquez, C. M. The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension. The dose of your acenocoumarol might need to be changed. 2007;3(3):129-138. View abstract. Nutrients 2021;13(10):3432. Does carnitine cause insomnia? Int J Clin Pharmacol Res 1988;8(5):367-376. More research is needed to confirm the benefits of L-carnitine in a younger, more active population. Andrologia. View abstract. Acta Anaesthesiol.Scand. Minerva Med 1989;80(3):227-231. View abstract. Eur J Obstet Gynecol Reprod Biol 2014;180:148-52. Reprod.Biomed.Online. Clin Ther 1995;17:176-85. View abstract. Last updated on Aug 31, 2022. Fulgente T, Onofrj M Del Re ML et al. Kidney Int 38 (1990): 904-11, 4. Pons-Rejraji H, Brugnon F, Sion B, Maqdasy S, Gouby G, Pereira B, Marceau G, Gremeau AS, Drevet J, Grizard G, Janny L, Tauveron I. View abstract. Ruggenenti, P., Cattaneo, D., Loriga, G., Ledda, F., Motterlini, N., Gherardi, G., Orisio, S., and Remuzzi, G. Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. Ann.Clin Psychiatry 2009;21(4):213-236. 2010;62(3):213-218. 2020;37:9-23. View abstract. Gomez-Amores, L., Mate, A., Miguel-Carrasco, J. L., Jimenez, L., Jos, A., Camean, A. M., Revilla, E., Santa-Maria, C., and Vazquez, C. M. L-carnitine attenuates oxidative stress in hypertensive rats. View abstract. However, L-carnitine supplements may raise your blood levels of trimethylamine-N-oxide (TMAO) over time. A., Hatfield, D. L., Vingren, J. L., Quann, E. E., Anderson, J. M., Maresh, C. M., and Kraemer, W. J. View abstract. Clinical and biochemical effects. Murakami K, Sugimoto T, Woo M, et al. Feillet, F., Ogier, H., Cheillan, D., Aquaviva, C., Labarthe, F., Baruteau, J., Chabrol, B., de, Lonlay P., Valayanopoulos, V., Garnotel, R., Dobbelaere, D., Briand, G., Jeannesson, E., Vassault, A., and Vianey-Saban, C. [Medium-chain acyl-CoA-dehydrogenase (MCAD) deficiency: French consensus for neonatal screening, diagnosis, and management]. Eur.J Cancer 7-19-2005; View abstract. Touati, G., Valayannopoulos, V., Mention, K., de, Lonlay P., Jouvet, P., Depondt, E., Assoun, M., Souberbielle, J. C., Rabier, D., Ogier de, Baulny H., and Saudubray, J. M. Methylmalonic and propionic acidurias: management without or with a few supplements of specific amino acid mixture. Turk.J Pediatr 1998;40(1):79-84. Boneh, A., Beauchamp, M., Humphrey, M., Watkins, J., Peters, H., and Yaplito-Lee, J. CNS.Drugs 2007;21 Suppl 1:25-30. Miyagawa T, Kawamura H, Obuchi M, Ikesaki A, Ozaki A, Tokunaga K, Inoue Y, Honda M. Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. Yet, there are a few known side effects that include agitation, insomnia and nausea. View abstract. 2011;28(4):393-400. Eur.J.Gen.Med 2009;6(2):7-15. Clin Nutr ESPEN 2021;46:54-59. View abstract. Hum.Reprod. Wadzinski, J., Franks, R., Roane, D., and Bayard, M. Valproate-associated hyperammonemic encephalopathy. J Inherit.Metab Dis 2010;33(5):555-561. Endocr Metab Immune Disord Drug Targets 2020. The Effects of L-Carnitine, Acetyl-L-Carnitine, and Propionyl-L-Carnitine on Body Mass in Type 2 Diabetes Mellitus Patients. Yano J, Kaida Y, Maeda T, et al. Helms, R. A., Mauer, E. C., Hay, W. W., Jr., Christensen, M. L., and Storm, M. C. Effect of intravenous L-carnitine on growth parameters and fat metabolism during parenteral nutrition in neonates. Eur.Urol. Some research suggests that L-carnitine may help prevent or reduce symptoms of an overactive thyroid, such as insomnia, nervousness, heart palpitations, and tremors. 2010;106(8):1181-1185. For this reason, L-carnitine levels are often lower in vegetarians and vegans, since they restrict or avoid animal products (6, 62). View abstract. Metabolism 2008;57(4):549-554. Effect of L-carnitine supplementation on acute valproate intoxication. Ghidini O, Azzurro M, Vita G, Sartori G. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. 2010;15(2):200-211. Clin Drug Investig. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized, placebo-controlled trials. Kubota K, Uojima H, Shao X, et al. Adv Exp Med Biol 1990;272:197-208. View abstract. 2017;96(39):e8117 View abstract. Available for Android and iOS devices. 2007;178(4 Pt 1):1398-1403. Eur Heart J 1994;15(10):1348-1352. 2019 Apr;27(4):1491-1496. A cross-over study vs placebo. View abstract. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. 2020;151:104554. Dial Transplant 1998;27:498-506. View abstract. Nutr J. BJU Int 2001;88:63-7.. View abstract. View abstract. Ciacci C, Peluso G, Iannoni E, et al. Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitus. Scarpini E, Sacilotto G, Baron P, et al. View abstract. View abstract. Taking L-carnitine with thyroid hormone might decrease the effectiveness of the thyroid hormone. According to one study, 5784% of L-carnitine is absorbed when its consumed from food, compared to only 1418% when taken as a supplement (61). Available at: https://www.fda.gov/orphan/designat/alldes.rtf. A. Sethumadhavan, S. and Chinnakannu, P. Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process. View abstract. View abstract. View abstract. Am J Clin Nutr 1989;49(2):283-289. Zhonghua Nan.Ke.Xue 2012;18(3):253-256. A., Yamamah, G. A. E., El-Baky, A. M. N. E. A., El-Kassas, G. M., and Elhalim, A. View abstract. Altunbasak S, Baytok V, Tasouji M, et al. 2009;32(1):35-40. [Effect of L-carnitine in patients with ischemic heart disease]. Eur J Clin Pharmacol 2019;75(8):1037-46. doi: 10.1007/s00228-019-02666-5. Sole MJ, Jeejeebhoy KN. Andrologia 2019;51(6):e13267. Z., Zhang, S. S., Zhang, Z., Liang, Q., Shi, Y., Hua, J. L., and Sun, T. [Expressions of sperm-specific genes in carnitine-cultured testis sperm of obstructive azoospermia patients]. Pola P, Savi M, Grilli M, and et al. DiNicolantonio, J. J., Lavie, C. J., Fares, H., Menezes, A. R., and O'Keefe, J. H. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. View abstract. 2010;105(6):1338-1345. More research is needed on long-term benefits for healthy individuals. De Ritis G, Picardo S, Brancadoro D, and et al. View abstract. Clin J Am Soc Nephrol. 2014 Nov 26;13:110. 1996;18(1):91-96. View abstract. Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. Cell Death.Dis 2010;1:e62. In an eight-week study in 38 women who exercised four times per week, there was no difference in weight loss between those who took L-carnitine and those who didnt (24). Berthillier G, Eichenberger D, Carrier HN, et al. Acta Paediatr 1996;85:446-9. View abstract. Am J Cardiol 1994;74:125-30. A., Ghaith, O., Medhat, T., George, S. K., and Elshafey, E. M. Is there a role for oral L-carnitine therapy in anemia and cardiac dysfunction management in Egyptian patients on maintenance hemodialysis? Minerva Cardioangiol. Although potent on its own, this supplement works best when stacked with other nootropics. Drug class: Nutraceutical products. 7-14-2009;89(26):1858-1861. View abstract. This medicine works best if you take it with a meal or within 30 minutes after a meal. View abstract. View abstract. Acta Paediatr Hung 1986;27:253-8. Aliment.Pharmacol Ther 2011;34(9):1088-1097. Tarantini, G., Scrutinio, D., Bruzzi, P., Boni, L., Rizzon, P., and Iliceto, S. Metabolic treatment with L-carnitine in acute anterior ST segment elevation myocardial infarction. View abstract. View abstract. View abstract. Effect of L-carnitine supplement on semen parameters in men with idiopathic infertility. View abstract. You can get small amounts of L-carnitine from your diet by eating meat and fish (4, 5). Rolim LC, da Silva EM, Flumignan RL, Abreu MM, Dib SA. 2006;12(6):704-714. Research shows that your levels tend to decline as you age (63, 64). Mingrone G, Greco AV, Capristo E, et al. II. View abstract. Neuromuscul.Disord. Saneian H, Khalilian L, Heidari-Beni M, et al. Background and aim: Clinical evidence which investigated the effects of l-carnitine, a vitamin-like substance, on weight loss had led to inconsistent results. 1998;32(2):258-264. Some animal studies suggest that the acetyl form, acetyl-L-carnitine (ALCAR), may help prevent age-related mental decline and improve markers of learning (30, 31). J Clin Hypertens.(Greenwich.) Nausea and vomiting Diarrhea Other possible side effects may include: Headaches and dizziness Insomnia Fatigue Skin itching or rashes Irritability or agitation The safety of use of CoQ10 during pregnancy and breast-feeding hasn't been established. J.Mazandaran Univ.Med.Sci. Noble S, Goa KL. In some people, carnitine can cause fishy body odor, abdominal cramps, nausea, vomiting, muscle weakness, rash, increases in appetite, diarrhea or body odor, especially with the high doses found in supplements. 2008;47(10):823-825. Jing, L., Zhou, L. J., Li, W. M., Zhang, F. M., Yuan, L., Li, S., Song, J., and Sang, Y. Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. 2011;18(1):18-22. [A systematic review of the effectiveness of alternative weight-loss products' ingredients]. Circ.J 2008;72(6):926-931. Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, et al. View abstract. View abstract. Anemia and carnitine supplementation in hemodialyzed patients. J Inherit.Metab Dis 2008;31 Suppl 2:S219-S222. View abstract. Stefan M, Sharp M, Gheith R, et al. Rett syndrome: randomized controlled trial of L-carnitine. Thal LJ, Carta A, Clarke WR, et al. For most individuals, the nausea and vomiting will be relatively mild. Carnitine, valproate, and toxicity. Symptoms include relentless fatigue during the day, not feeling rested after sleep, insomnia, reduced sex drive, a "wired and tired" feeling, a reduced ability to concentrate and feel relaxed, and weight gain, especially in the stomach. Gen Thorac Cardiovasc Surg 2021;69(11):1460-1466. Curran, J. S., Williams, P. R., Kanarek, K. S., Novak, M., and Monkus, E. F. An evaluation of orally supplemented L-carnitine in premature infants receiving Intralipid 20%. Metabolism Boosters: Weight Loss Fact or Fiction? View abstract. View abstract. Int J Sports Med 1994;15(4):181-185. Sato S, Namisaki T, Furukawa M, et al. Pola, P., Tondi, P., Flore, R., Serricchio, M., Dal Lago, A., Amanti, C., Consorti, F., Benedetti, M., and Midiri, H. Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid. Clin Genet. Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers. View abstract. Epilepsia 1996;37:687-9. 1988;26(5):269-272. View abstract. View abstract. Basic Clin Pharmacol Toxicol. View abstract. Efficacy and safety of adefovir dipivoxil with antiretroviral therapy. L-carnitines benefits may be indirect and take weeks or months to appear. J Cardiol 1991;21(2):493-504. Psychopharmacology (Berl) 2004;175(1):84-91. 10-21-2011;17(39):4414-4420. Current Therapeutic Reserch 1983;33(6):1098-1104. View abstract. 150mg ala, and 500mg carnitine. 1997;37(3 Pt 1):491-493. 2005;45(6):343-351. View abstract. Lisinopril (lisinipril) can cause nausea, headaches, anxiety, insomnia, drowsiness, nasal congestion and sexual dysfunction. 1979;43(2):300-306. Brevetti G, Perna S, Sabba C, et al. Safarinejad, M. R., Hosseini, S. Y., and Kolahi, A. Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. View abstract. Sakurabayashi, T., Miyazaki, S., Yuasa, Y., Sakai, S., Suzuki, M., Takahashi, S., and Hirasawa, Y. L-carnitine supplementation decreases the left ventricular mass in patients undergoing hemodialysis. 2006;115(1-2):91-96. View abstract. Drugs Exp Clin Res 1991;17:225-35. View abstract. Pollard, L. M., Williams, N. R., Espinoza, L., Wood, T. C., Spector, E. B., Schroer, R. J., and Holden, K. R. Diagnosis, treatment, and long-term outcomes of late-onset (type III) multiple acyl-CoA dehydrogenase deficiency. J Pediatr Gastroenterol Nutr 1987;7:220-224. While it may aid in weight loss for obese individuals or older adults, a thorough diet and exercise regimen must be in place first. Bernard, A., Rigault, C., Mazue, F., Le, Borgne F., and Demarquoy, J. L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat. High levels of TMAO are linked to an increased risk of atherosclerosis a disease which clogs your arteries (59, 60). View abstract. View abstract. McMackin, C. J., Widlansky, M. E., Hamburg, N. M., Huang, A. L., Weller, S., Holbrook, M., Gokce, N., Hagen, T. M., Keaney, J. F., Jr., and Vita, J. Lancet 2 (1980): 763-4, 5. 2007;18(3):169-176. View abstract. Fenkci, S. M., Fenkci, V., Oztekin, O., Rota, S., and Karagenc, N. Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome. J Strength.Cond.Res. Perna, A. F., Acanfora, F., Satta, E., Lombardi, C., Capasso, R., Ingrosso, D., and De Santo, N. G. L-Propionyl carnitine, homocysteine and S-adenosylhomocysteine in hemodialysis. View abstract. Neurological: headaches, dizziness. Schiavoni, G., Lucente, M., Di Folca, A., Alessandri, N., Mongiardo, R., and Manzoli, U. Derosa, G., Maffioli, P., Ferrari, I., D'Angelo, A., Fogari, E., Palumbo, I., Randazzo, S., and Cicero, A. F. Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients. Karalis DT, Karalis T, Karalis S, Kleisiari AS. I fell asleep at night but woke up repeatedly and then couldn't get back to sleep. The effect of L-carnitine on mortality rate in septic patients: a systematic review and meta-analysis on randomized clinical trials. Maggi GC, Lomanto B, and Mazzola, C. Double-blind multicenter clinical trial on the efficacy of phosphocreatinine vs L-carnitine and placebo in a group of patients affected by heart disease. Cochrane.Database.Syst.Rev. J Drug Dev 1988;1(3):163-166. Ann.Pharmacother. L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis. Propionyl-L-carnitine is safe for most people when taken by mouth or given intravenously by a healthcare professional. Colon-Soto, M., Peredo, R. A., and Vila, L. M. Systemic lupus erythematosus after mesotherapy with acetyl-L-carnitine. Singh RB, Niaz MA, Agarwal P, et al. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. As noted before, your body can also produce this substance naturally from the amino acids methionine and lysine if your stores are low. 1996;208(3):129-134. View abstract. J Am Soc Nephrol 2002;13:708-14.. View abstract. Z., Wang, L. X., Liu, H. Z., Qi, X. W., Wang, X. H., and Ren, H. Z. L-carnitine as an adjunct therapy to percutaneous coronary intervention for non-ST elevation myocardial infarction. In cells, it helps transport fatty acids into the mitochondria, where they can be burned for energy. . Interaction with zidovudine. Biol.Neonate 1987;51(4):185-193. Desbree, A., Houdon, L., Touati, G., Djemili, S., Choker, G., and Flodrops, H. [EBV infection revealing a long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency in a 3-year-old boy]. I noticed very sensitive teeth and gums for awhile, but seems to have . Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double-blind crossover field study. Feinfeld, D. A., Kurian, P., Cheng, J. T., Dilimetin, G., Arriola, M. R., Ward, L., Manis, T., and Carvounis, C. P. Effect of oral L-carnitine on serum myoglobin in hemodialysis patients. Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral . 2009;47(9):748-753. Clin Hemorheol.Microcirc. More severe and rarer side effects are seizures and muscle weakness in people prone to heart disease [ 38 ]. This differs from supplements like caffeine or creatine, which can directly enhance sports performance. Milazzo, L., Menzaghi, B., Caramma, I., Nasi, M., Sangaletti, O., Cesari, M., Zanone, Poma B., Cossarizza, A., Antinori, S., and Galli, M. Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study. View abstract. Newer research illustrates the potential benefits of carnitines different forms, which may be used for various conditions, including heart and brain diseases (22, 23). J Eur Acad Dermatol Venereol 1999;13:205-9. 2007;29(8):517-530. (Cruciani et al., 2004). View abstract. De Vecchi, A. F., Arduini, A., Di, Liberato L., and Bonomini, M. [L-carnitine in peritoneal dialysis]. De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. Cochrane.Database.Syst.Rev. 2003;21(3):271-275. Hollyer T, Boon H, Georgousis A, et al. View abstract. Serjeant, B. E., Harris, J., Thomas, P., and Serjeant, G. R. Propionyl-L-carnitine in chronic leg ulcers of homozygous sickle cell disease: a pilot study. View abstract. Gentile, V., Antonini, G., Antonella, Bertozzi M., Dinelli, N., Rizzo, C., Ashraf, Virmani M., and Koverech, A. J Pharm Sci 1995;84(5):627-633. View abstract. Tempesta E, Casella L, Pirrongelli C, et al. Optom.Vis.Sci 2011;88(12):1439-1444. View abstract. View abstract. View abstract. View abstract. View abstract. Pignatelli, P., Tellan, G., Marandola, M., Carnevale, R., Loffredo, L., Schillizzi, M., Proietti, M., Violi, F., Chirletti, P., and Delogu, G. Effect of L-carnitine on oxidative stress and platelet activation after major surgery. Calabrese, V., Giuffrida Stella, A. M., Calvani, M., and Butterfield, D. A. Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes. J Pediatr 1986;109(6):984-988. Fertil Steril 2002;78:1203-8.. View abstract. Medically reviewed by Drugs.com. Diabetes Care 2005;28:89-94. Jones, S., Reed, C. A., Vijay, S., Walter, J. H., and Morris, A. Greig, C., Finch, K. M., Jones, D. A., Cooper, M., Sargeant, A. J., and Forte, C. A. View abstract. Carnitine and physical exercise. View abstract. Int J Curr Res Acad Rev 2015;3:469-76. AIDS Res.Hum.Retroviruses 2010;26(11):1207-1214. Urol.J 2010;7(3):188-193. Nat.J.Andro. View abstract. Kletzmayr J, Mayer G, Legenstein E, et al. View abstract. View abstract. Int.J Vitam.Nutr.Res. Taking your CoQ10 with food not only helps . 2006;49(6):987-997. View abstract. J Clin Oncol. Lund, A. M., Joensen, F., Hougaard, D. M., Jensen, L. K., Christensen, E., Christensen, M., Norgaard-Petersen, B., Schwartz, M., and Skovby, F. Carnitine transporter and holocarboxylase synthetase deficiencies in The Faroe Islands. View abstract. Megri K, Trombert JC Zannier A. The main dietary sources of L-carnitine are meat, fish and some other animal products, such as milk. View abstract. Bohmer, T., Boen, A., and Hoymork, S. C. Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. 2010;34(3):295-299. View abstract. Salonia, A. AIDS 2004;18:1549-60. Bijarnia, S., Wiley, V., Carpenter, K., Christodoulou, J., Ellaway, C. J., and Wilcken, B. Glutaric aciduria type I: outcome following detection by newborn screening. Rossignol, D. A. and Frye, R. E. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Idiopathic facial paralysis: new therapeutic prospects with acetyl-L-carnitine. Perrott, J., Murphy, N. G., and Zed, P. J. L-carnitine for acute valproic acid overdose: a systematic review of published cases. View abstract. Heinonen OJ. Neurol 2000;55:805-10. However, one analysis of nine studies mostly in obese individuals or older adults found that people lost an average of 2.9 pounds (1.3 kg) more weight while taking L-carnitine (29). View abstract. Rajasekar, P., Palanisamy, N., and Anuradha, C. V. Increase in nitric oxide and reductions in blood pressure, protein kinase C beta II and oxidative stress by L-carnitine: a study in the fructose-fed hypertensive rat. G.Ital.Cardiol. 2008;22(4):1130-1135. View abstract. De Simone C, Catania S, Trinchieri V, and et al. It helps transport fatty acids into the mitochondria where they can be burned up and used as fuel. View abstract. Latifian S, Hamdi K, Totakneh R. Effect of addition of l-carnitine in polycystic ovary syndrome (PCOS) patients with clomiphene citrate and gonadotropin resistant. Z., Mandalidis, D., Taxildaris, K., and Vargemezis, V. Effects of L-carnitine on oxidative stress responses in patients with renal disease. 1980;4(1):23-34. View abstract. A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia. View abstract. Propionyl carnitine in stable effort angina. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.